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ID: ZDB-GENE-980526-118; Name: neurotrophic tyrosine kinase, receptor, type 1; Symbol: ntrk1 Nomenclature History; Previous Names. trk; trkA (1). Aug 18, 2020 The NTRK1 gene provides instructions for making a protein that is essential for the development and survival of nerve cells (neurons), Dec 1, 2018 encoded by the genes neurotrophic tyrosine receptor kinase 1, 2, and 3 ( NTRK1, detected two novel NTRK1 gene fusion partners: Myosin. Jul 28, 2020 The NTRK1 gene provides instructions for making a protein that is neurotrophic tyrosine kinase receptor type 1 gene, NTRK1, encoding the Background: Neurotrophic Tropomyosin Kinase Receptor 1 (NTRK1) gene encodes for the protein Tropomyosin-related kinase A (TRKA). A deregulated activity Dec 7, 2020 An oncogenic neurotrophic tyrosine receptor kinase 1 (NTRK1) gene fusion cloned from a colon cancer sample was first reported in 1982 Jan 22, 2019 In 1996, Indo et al first identified neurotrophic tyrosine kinase receptor type 1 ( NTRK1) mutations in three unrelated CIPA patients. The gene NTRK gene fusions lead to abnormal proteins called TRK fusion proteins, which may cause cancer cells to grow.

Ntrk1 gene

NTRK1, 3. Aktiverande punktmutation, translokation. Thyroidea, bröst, colon. Uncharacterized protein OS=Canis familiaris GN=NTRK1 PE=4 SV=1 N-Myc downstream regulated gene 1 OS=Canis familiaris GN=NDRG1 PE=2 SV=1 I >tr|A5YRP0|A5YRP0_PIG B-cell translocation gene 1 OS=Sus scrofa GN=BTG1 Tyrosine-protein kinase receptor OS=Sus scrofa GN=NTRK1 PE=3 SV=1 kinase (Aspergillus nidulans) -- Fused: fused gene product (D.

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Description neurotrophic receptor tyrosine kinase 1. Also known as MTC, TRK, TRK1, TRKA, Trk-A, The human TRKA gene (NTRK1), located on chromosome 1q21-q22 encodes the receptor tyrosine kinase for nerve growth factor.

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Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 [ (house mouse)] Gene ID: 18211 , updated on 13-Oct-2020 Functional Associations.

The TRK receptor family comprises 3 transmembrane proteins referred to as TRKA, TRKB, and TRKC, encoded by the NTRK1, NTRK2, and NTRK3 genes, respectively TRK receptors are typically expressed in human neuronal tissue and play an essential role in the physiology, development, and function of the nervous system through activation by neurotrophins GeneCards Summary for NTRK1 Gene: NTRK1 (neurotrophic tyrosine kinase, receptor, type 1) is a protein-coding gene. Diseases associated with NTRK1 include congenital insensitivity to pain with anhidrosis, and anhidrosis. GO annotations related to this gene include ephrin receptor binding and protein homodimerization activity. NTRK1 fusions trigger constitutive TRKA kinase activity (PMID: 24162815), which activates cell growth and differentiation pathways (PMID: 12652644).
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The causative NTRK1 mutations lead to loss of function of the TrkA protein, an important ligand for nerve growth factor (NGF), and therefore induce various clinical phenotypes associated with neuron maturation defects. Materials and methods: Three patients from unrelated families with CIPA were subjected to detailed clinical examinations. Gene name: NTRK1 (HGNC Symbol) Synonyms: MTC, TRK, TRKA: Description: Neurotrophic receptor tyrosine kinase 1 (HGNC Symbol) Chromosome: 1: Cytoband: q23.1: Chromosome location (bp) 156815640 - 156881850: Number of transcripts i NTRK1 is associated with 1 reactions in 1 different subsystems: Cytosol.

NTRK1- och MET-gener: Mutationer i dessa gener har också associerats med papillär sköldkörtelcancer. RAS onkogen: Förändringar i RAS-onkogen återfinns i ENSG00000232725 Gene - GeneCards | ENSG00000232725 RNA Gene. SSR4 Gene - GeneCards | SSRD Protein | SSRD Antibody.
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See NTRK RNA Targeted Gene Fusions table in Special Instructions for details. NTRK gene fusion is the primary mechanism of oncogenic activation of TRK proteins.

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Protein attributes for NTRK1 Gene Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Sequence=CAA27243.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence= {ECO:0000305}; Sequence=CAA27243. Trk also stands for tropomyosin-related 2021-03-29 · NTRK1 gene is associated with Alzheimer's disease in Italian population. NGF/TrkA signaling contributes to aberrant signaling in chronic myelogenous leukemia. TrkA receptor endolysosomal degradation is both ubiquitin and proteasome dependent; Melanoma cells express the low-affinity (p75NTR) and the high-affinity tyrosine kinase NT receptors (Trk).