Reag Apolipoprotein A-1, flyt, IT, R1 4x60 ml, R2 4x36 ml

Specific Protein Portfolio - Roche Diagnostics

Lär dig om vilken roll Apo A1 spelar. Testa dig idag! Föreningen aktiverar lecitin-kolesterol acyltransferas, som bildar kolesterylestrar i högdensitetslipoproteinerna (HDL). Genen för detta apolipoprotein återfinns  Apolipoprotein A-II(Apo-AII for short), also known as Apolipoprotein A2, is a secreted protein which belongs to the apolipoprotein A2 family. It exists as a  Apo B förekommer endast som en molekyl per lipoproteinpartikel.

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1988-08-01 2021-04-06 BACKGROUND: The lipoprotein(a) pathway is a causal factor in coronary heartdisease. We used a genetic approach to distinguish the relevance of two distinct components of this pathway, apolipoprotein(a) isoform size and circulatinglipoprotein(a) concentration, to coronary heart disease. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.

P/S-Apolipoprotein A-1

Application: Apo A-I and apo B may be measured as an alternative to HDL and LDL cholesterol respectively in the assessment of atherosclerosis risk factors, and may offer better prediction of risk. Apolipoprotein A-I (apo A-I) is a protein that has specific roles in the transportation and metabolism of lipids and is the main protein component in high-density lipoprotein (HDL, the "good cholesterol"). This test measures the amount of apo A-I in the blood. Lipids alone cannot dissolve in the blood; they are like oil that floats on water.

SÄKERHETSDATABLAD - Agilent

Provtagning med hög klinisk standard i samarbete med bl.a. Karolinska Universitetslaboratoriet.

https://doi.org/10.1016/j.biocel.2013.05.021 Elevated levels of apolipoprotein (apo) B, a constituent of atherogenic lipoproteins, and reduced levels of apo A-I, a component of anti-atherogenic HDL, are associated with increased cardiac events. Apo B, apo A-I and the apo B/apo A-I ratio have been reported as better predictors of cardiovascular events than LDL-C and they even retain their predictive power in patients receiving lipid Using proteomic techniques, apolipoprotein A-I (ApoA-I) has been found at decreased levels in subjects with a variety of neurodegenerative disorders including in the serum and cerebrospinal fluid (CSF) of Alzheimer disease (AD), Parkinson disease (PD) and Down syndrome (DS) with gout subjects. Apolipoproteins are polar structures which provide structural stability to the lipoprotein and act as receptors that help to determine the fate of the particle. Some act as cofactors for enzymes involved in lipid and lipoprotein metabolism. 1997-10-21 The inverse relationship between high density lipoprotein (HDL) plasma levels and coronary heart disease has been attributed to the role that HDL and its major constituent, apolipoprotein A-I (apoA-I), play in reverse cholesterol transport (RCT). The efficiency of RCT depends on the specific ability … An apolipoprotein A-I that is encoded in the genome of human.
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Thus, the Apo B/Apo A1 ratio may be a better risk predictor of atherosclerotic disease than the LDL/HDL ratio. 9 Abstract. Although LDL cholesterol (LDL-C) is associated with an increased risk of coronary heart disease, other lipoproteins and their constituents, apolipoproteins, may play an important role in atherosclerosis. Elevated levels of apolipoprotein (apo) B, a constituent of atherogenic lipoproteins, and reduced levels of apo A-I, a component of anti-atherogenic HDL, are associated with increased cardiac events.

Deficiency of apo A1 is associated with HDL deficiencies, including Tangier disease and systemic non-neuropathic amyloidosis. Apo A1 may have a role in protection against Alzheimer's disease. Apo A-1 comprises 60% to 70% of the protein content of HDL. Apo A-1 serves as an activator of LCAT which is involved in the transport of cholesterol from peripheral tissues to the liver where it is degraded.
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P/S-Apolipoprotein A-1

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